Introducing the New Maestro Pro & Edge
From heartbeats to brain function,
excitable cells play a fundamental role in life.
The evaluation of electrically active cells has historically been tedious, requiring months of training to study single cells at a low throughput.
With Maestro MEA technology, any scientist can now quickly and easily measure electrical network behavior in live cells at high throughput.
Now there’s nothing to stop you from exploring life’s circuitry.
Axion products are used by researchers across the globe for disease modeling, drug discovery, toxicology and basic research. Below are some examples of how Maestro MEA technology is helping us to understand more about how the brain, heart, and muscles function.
RESTORING FRAGILE X NEURON FUNCTION WITH GENE EDITING
RECREATING IRREGULAR HEART BEATS WITH PATIENT CELLS AND GENE EDITING
BUILDING A LIGHT CONTROLLED NEUROMUSCULAR JUNCTION
Diseases that impair the functioning of muscles, either directly or indirectly via motor neurons, are referred to as neuromuscular disorders (e.g. ALS and myasthenia gravis). Although there is a strong genetic understanding of many of these disorders, the poor translatability of animal models to humans has hindered the development of treatments for these diseases. Consequently, there is a need for a model that more faithfully recapitulates the physiology of the human neuromuscular junction. In this Coffee Break Webinar, Elliot Swartz (UCLA) discusses how he is building a light controlled hiPSC model of a neuromuscular junction to help better understand neuromuscular disorders.
Learn how MEA Assays work and the innovation behind Axion’s products.
WHAT IS MEA?
Axion’s microelectrode array (MEA) plates have a grid of tightly spaced electrodes embedded in the culture surface of each well [A]. Electrically active cells, such as neurons or cardiomyocytes, can be cultured over the electrodes [B]. Over time, as the cultures become established, they form cohesive networks and present an electrophysiological profile. The resulting electrical activity—spontaneous or induced firing of neurons, or the uniform beat of cardiomyocytes—is captured from each electrode on a microsecond timescale providing both temporally and spatially precise data [C].
NEURAL NETWORK RECORDINGS
Electrical activity is captured from neurons (orange) cultured over electrodes (gray circle). The Maestro MEA system detects key parameters of neural network activity, including functionality, excitability, and connectivity.
The Maestro MEA system detects key parameters of cardiomyocyte activity, including depolarization, propagation of excitibitality, repolarization, beat timing and irregular beating (arrhythmia).
Connect to Your Network
“One Button Setup”
Temperature and CO2 levels automatically adjust on plate docking. Plate usage is logged via an integrated plate barcode scanner for convenient experiment tracking.
The smart environmental chamber finely controls heat and CO2 while rejecting electrical noise and mechanical vibrations.
Powerful Data Analysis
AxIS Navigator simplifies the setup, execution, and analysis of MEA experiments.
Join us for your coffee break
Networks of excitable cells play a fundamental role in life, from the beating heart to the conscious brain. In the time it takes to drink your coffee, experts in the field will explain how they are using Axion’s technology to better understand life’s circuitry.
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